CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-Making
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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CRISPR is currently viewed as the central tool for future gene therapy. Yet, many prominent scientists and bioethicists have expressed ethical concerns around CRISPR gene therapy. This paper provides a critical review of concerns about CRISPR gene therapy as expressed in the mainstream academic literature, paired with replies also generally found in that literature. The expressed concerns can be categorised into three types depending on whether they stress risk/benefit ratio, autonomy and informed consent, or concerns related to various aspects of justice. In the reviewed literature, we found no intrinsic objections to CRISPR gene therapy, even though many such objections were present in discussions of gene editing in the 1990s. The paper then proposes a brief outline for a practically applicable moral framework for public decision-making about CRISPR gene therapy and suggests how such a framework might be supported. We also suggest that this framework should govern public engagement about CRISPR gene therapy in order to reduce the risk that we make decisions about CRISPR gene therapy based on misperceptions, inflated views of risk, or unreasonable moral or religious views.
Originalsprog | Engelsk |
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Tidsskrift | Canadian Journal of Bioethics |
Vol/bind | 5 |
Udgave nummer | 2 |
Sider (fra-til) | 78-87 |
Antal sider | 10 |
ISSN | 1923-2799 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Work on this paper was generously funded by the Novo Nordisk Foundation as a part of the project Convergent Ethics and Ethics of Controversy (CEEC). Thanks to Andreas Christiansen, Bjørn Gunnar Hallsson, Alexander Heape, Katla Hedinsdottir, Nanna Cecilie Halmsted Kongsholm, Gina Labovic, Jonas Aske Dam Rasmussen, Johan Jensen, Niels Gustav Døcker Husum, and Annika Andersen for comments and critical discussion of earlier drafts.
Publisher Copyright:
© Victor Lange and Klemens Kappel, 2022.
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